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Solid Tumors
Amol Ghia, MD
MD Anderson Cancer Center
Summary:
Up to 40% of all cancer patients develop metastatic disease involving the spine. This can severely impact patients’ quality of life by causing pain, weakness, bowel and bladder dysfunction, paralysis, or fractures. To treat these metastases, there is an advanced form of radiation therapy called spine stereotactic radiosurgery which is non-invasive. However, one of the possible adverse events of this therapy is vertebral compression fractures which can occur in up to 40% of patients after radiosurgery. This phase II study aims to assess whether giving bone cement, which has been used successfully in other diseases such as osteoporosis, prior to spine stereotactic radiosurgery can prevent these vertebral fractures in patients with spinal metastases.
Trial Registration: ClinicalTrials.gov Identifier: NCT02387905