Over the past two decades, there has been an increased clinical interest in structured exercise therapy as a supplemental intervention following a cancer diagnosis – a field now known as exercise-oncology. The majority of these efforts in exercise-oncology investigated the role of exercise to help patients prepare for, tolerate, or recover from cancer treatments, focusing on outcomes such as quality of life, fatigue, and physical functioning. It is known that cancer cells have an increased demand for nutrients, growth factors, and hormones to support hyperproliferation. Exercise therapy may be an attractive and cost-effective, non-pharmacological approach to target the metabolic reprogramming of tumor cells in patients. This study will extend beyond whether exercise can help patients cope with cancer and cancer treatment and will ultimately determine if structured exercise therapy can slow the progression of cancer.
Trial Registration: ClinicalTrials.gov Identifier: NCT03813615