DONATE

Acknowledged and Supported Publications

  1. Gruber TA, Jeha S, Deyell RJ, et al. Bortezomib and vorinostat in combination with mitoxantrone, dexamethasone, and pegasparaginase during induction and reinduction for infants with acute lymphoblastic leukaemia: a multicentre single-arm phase 1/2 study. Lancet Haematol. 2026;S2352-3026(25)00357-6. doi:10.1016/S2352-3026(25)00357-6
  2. Easty D, McDermott R, Murphy AG, et al. Early termination of NCT04617067, a phase II, open label, clinical trial of oral paricalcitol in combination with gemcitabine and nab-paclitaxel therapy in advanced pancreatic cancer. BMC Cancer. 2026;26(1):255. doi:10.1186/s12885-025-14512-2
  3. Katayama ES, Hue JJ, Loftus AW, et al. Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker. Noncoding RNA Res. 2025;15:132-141. doi:10.1016/j.ncrna.2025.08.001
  4. Miszczyk M, Abrams RA, Lawrence YR. Beyond opioids in pancreatic cancer: palliative radiotherapy and celiac plexus radiosurgery. Semin Radiat Oncol. 2025;35(4):546-555. doi:10.1016/j.semradonc.2025.07.005
  5. Schiff D, Ye X, Li J, et al. Phase I/II and window-of-opportunity study of pamiparib and metronomic temozolomide for recurrent IDH mutant gliomas. Neuro Oncol. 2025 :noaf246. doi:10.1093/neuonc/noaf246
  6. Fernandez E, Vernet R, Urwyler M, et al. Overall survival of recurrent/metastatic head & neck squamous cell carcinoma patients progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy: results of SAKK 11/16, a phase IIa trial. Exp Hematol Oncol. 2025;14(1):113. doi:10.1186/s40164-025-00703-x
  7. Wolf DM, Yau C, Campbell M, et al. Immune subtyping identifies patients with hormone receptor-positive early-stage breast cancer who respond to neoadjuvant immunotherapy (IO): results from five IO arms of the I-SPY2 trial. JCO Precis Oncol. 2025;9:e2400776. doi:10.1200/PO-24-00776
  8. Moon DH, Avkshtol V, Hughes RS, et al. HYHOPE: a phase 1 study of deintensified hypofractionated radiation therapy for human papillomavirus-associated oropharynx cancer. Int J Radiat Oncol Biol Phys. 2025;123(3):694-702. doi:10.1016/j.ijrobp.2025.05.009
  9. Demeestere I, Niman SM, Partridge AH, et al; International Breast Cancer Study Group and The POSITIVE Trial Collaborators. Hormonal factors predictive of fertility in patients with breast cancer interrupting adjuvant endocrine therapy to attempt pregnancy in POSITIVE trial. Breast. 2025;83:104547. doi:10.1016/j.breast.2025.104547
  10. Morder KM, Nguyen M, Wilfahrt DN, et al. Sucralose consumption ablates cancer immunotherapy response through microbiome disruption. Cancer Discov. 2025;15(11):2278-2297. doi:10.1158/2159-8290.CD-25-0247
  11. Schmid D, Sobottka B, Manzo M, et al. Tumor immune dynamics and long-term clinical outcome of stage IIIA NSCLC patients treated with neoadjuvant chemoimmunotherapy. Nat Commun. 2025;16(1):8673. doi:10.1038/s41467-025-63696-5
  12. Paccatori FA, Niman SM, Partridge AH, et al; International Breast Cancer Study Group and the POSITIVE Trial Collaborators. Breastfeeding after hormone receptor-positive breast cancer: results from the POSITIVE trial. J Clin Oncol. 2025;43(24):2712-2719. doi:10.1200/JCO-24-02697
  13. Lee A, Cole BL, Ojemann J, et al. Phase 1 and expanded imaging study of tozuleristide in patients with pediatric primary central nervous system tumors. J Neurosurg Pediatr. 2025;36(5):582-592. doi:10.3171/2025.5.PEDS24630
  14. Shapiro RM, Sheffer M, Booker MA, et al. First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer. J Hematol Oncol. 2025;18(1):17. doi:10.1186/s13045-025-01669-3
  15. Shah NN, Schafer ES, Chi YY, et al. Vincristine sulfate liposome injection with combination chemotherapy for children, adolescents, and young adults with relapsed acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia and lymphoma consortium trial. Pediatr Blood Cancer. 2025;72(5):e31584. doi:10.1002/pbc.31584
  16. Braun DA, Moranzoni G, Chea V, et al. A neoantigen vaccine generates antitumour immunity in renal cell carcinoma. Nature. 2025;639(8054):474-482. doi:10.1038/s41586-024-08507-5
  17. Underwood, WP, Michalski MG, Lee CP, et al. A digital, decentralized trial of exercise therapy in patients with cancer. NPJ Digit Med. 2024;7(1):304. doi:10.1038/s41746-024-01288-1
  18. Stein L, Murugesan K, Reeser JW, et al. FGFR2-fusions define a clinically actionable molecular subset of pancreatic cancer. NPJ Precis Oncol. 2024;8(1):207. doi:10.1038/s41698-024-00683-x
  19. Zarei M, Hajihassani O, Hue JJ, et al. IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer. Cancer Res. 2024;84(18):3072-3085. doi:10.1158/0008-5472.CAN-23-1895
  20. Lawrence YR, Miszczyk M, Dawson LA, et al. Celiac plexus radiosurgery for pain management in advanced cancer: a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2024;25(8):1070-1079. doi:10.1016/S1470-2045(24)00223-7
  21. Jones LW, Moskowitz CS, Lee CP, et al. Neoadjuvant exercise therapy in prostate cancer: a phase 1, decentralized nonrandomized controlledtrial. JAMA Oncol. 2024;10(9):1187-1194. doi:10.1001/jamaoncol.2024.2156
  22. Azim HA Jr, Niman SM, Partridge AH, et al. Fertility preservation and assisted reproduction in patients with breast cancer interrupting adjuvant endocrine therapy to attempt pregnancy. J Clin Oncol. 2024;42(23):2822-2832. doi:10.1200/JCO.23.02292
  23. Sussman TA, Severgnini M, Giobbie-Hurder A, et al. Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma. Front Oncol. 2024;14:1395978. doi:10.3389/fonc.2024.139597
  24. Khandelwal P, Langenberg L, Luebbering N, et al. A randomized phase 2 trial of oral vitamin A for graft-versus-host disease in children and young adults. Blood. 2024;143(12):1181-1192. doi:10.1182/blood.2023022865
  25. Choi BD, Gerstner ER, Frigault MJ, et al. Intraventricular CARv3-TEAM-E T cells in recurrent glioblastoma. N Engl J Med. 2024;390(14):1290-1298. doi:10.1056/NEJMoa2314390
  26. Brown CE, Hibbard JC, Alizadeh D, et al. Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial. Nat Med. 2024;30(4):1001-1012. doi:10.1038/s41591-024-02875-1
  27. Albain KS, Yau C, Petricoin EF, et al. Neoadjuvant trebananib plus paclitaxel-based chemotherapy for stage II/III breast cancer in the adaptively randomized I-SPY2 trial-efficacy and biomarker discovery. Clin Cancer Res. 2024;30(6):729-740. doi:10.1158/1078-0432.CCR-22-2256
  28. Petronek MS, Bodeker KL, Lee CY, et al. Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: insights from a phase 2 clinical trial. J Neurooncol. 2024;166(3):493-501. doi:10.1007/s11060-024-04571-z
  29. Verma A, Chi YY, Malvar J, et al. Nivolumab plus 5-azacitidine in pediatric relapsed/refractory acute myeloid leukemia (AML): phase I/II trial results from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. Cancers (Basel). 2024;16(3):496. doi:10.3390/cancers16030496
  30. Petronek MS, Monga V, Bodeker KL, et al. Magnetic resonance imaging of iron metabolism with T2* mapping predicts an enhanced clinical response to pharmacologic ascorbate in patients with GBM. Clin Cancer Res. 2024;30(2):283-293. doi:10.1158/1078-0432.CCR-22-3952
  31. Petronek MS, Teferi N, Lee CY, Magnotta VA, Allen BG. MRI detection and therapeutic enhancement of ferumoxytol internalization in glioblastoma cells. Nanomaterials (Basel). 2024;14(2):189. doi:10.3390/nano14020189
  32. Ceolin A, Ishimaru S, Karol SE, et al. The PedAL/EuPAL project: a global initiative to address the unmet medical needs of pediatric patients with relapsed or refractory acute myeloid leukemia. Cancers (Basel). 2023;16(1):78. doi:10.3390/cancers16010078
  33. Gallagher RI, Wulfkuhle J, Wolf DM, et al. Protein signaling and drug target activation signatures to guide therapy prioritization: therapeutic resistance and sensitivity in the I-SPY 2 trial. Cell Rep Med. 2023;4(12):101312.  doi:10.1016/j.xcrm.2023.101312
  34. Zaher A, Mapuskar KA, Sarkaria JN, Spitz DR, Petronek MS, Allen BG. Differential H2O2 metabolism among glioblastoma subtypes confers variable responses to pharmacological ascorbate therapy combined with chemoradiation. Int J Mol Sci. 2023;24(24):17158. doi:10.3390/ijms242417158
  35. Zhao JL, Antonarakis ES, Cheng HH, et al. Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC). Br J Cancer. 2024;130(1):53-62. doi:10.1038/s41416-023-02487-5
  36. Pabst T, Norbert V, Adès L, et al. Results from a phase I/II trial of cusatuzumab combined with azacitidine in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive chemotherapy. Haematologica. 2023;108(7):1793-1802. doi:10.3324/haematol.2022.281563
  37. Iskandarani SE, Sun L, Li SQ, Pereira G, Giralt S, Deng G. Acupuncture improves certain aspects of sleep in hematopoietic stem cell transplantation patients: a secondary analysis of a randomized controlled trial. Acupunct Med. 2023;41(6):319-326. doi:10.1177/09645284231181403
  38. Petronek MS, Bayanbold K, Amegble K, et al. Evaluating the iron chelator function of sirtinol in non-small cell lung cancer. Front Oncol. 2023;13:1185715. doi:10.3389/fonc.2023.1185715
  39. Partridge AH, Niman SM, Ruggeri M, et al; International Breast Cancer Study Group; POSITIVE Trial Collaborators. Interrupting endocrine therapy to attempt pregnancy after breast cancer. N Engl J Med. 2023;388(18):1645-1656. doi:10.1056/NEJMoa2212856
  40. Callaghan CM, Abukhiran IM, Masaadeh A, et al. Manipulation of redox metabolism using pharmacologic ascorbate opens a therapeutic window for radio-sensitization by ATM inhibitors in colorectal cancer. Int J Radiat Oncol Biol Phys. 2023;115(4):933-944. doi:10.1016/j.ijrobp.2022.10.012
  41. Petronek MS, Teferi N, Caster JM, et al. Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate. Redox Biol. 2023;62:102651. doi:10.1016/j.redox.2023.102651
  42. Petronek MS, Allen BG. Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex. Front Genet. 2023;14:1152398. doi:10.3389/fgene.2023.1152398
  43. Mamot C, Wicki A, Hasler-Strub U, et al. A multicenter phase II trial of anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative breast cancer. Sci Rep. 2023;13(1):3705. doi:10.1038/s41598-023-30950-z
  44. Vaishampayan UN, Thakur A, Chen W, et al. Phase II trial of pembrolizumab and anti-CD3 x anti-HER2 bispecific antibody-armed activated T cells in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2023;29(1):122-133. doi:10.1158/1078-0432.CCR-22-1601
  45. Gunther JR, Chadha AS, Guha S, et al. A phase II randomized double blinded trial evaluating the efficacy of curcumin with pre-operative chemoradiation for rectal cancer. J Gastrointest Oncol. 2022;13(6):2938-2950. doi:10.21037/jgo-22-259
  46. Heumann TR, Baretti M, Sugar EA, et al. A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence. Clin Epigenetics. 2022;14(1):166. doi:10.1186/s13148-022-01367-8
  47. Silk AW, O’Day SJ, Kaufman HL, et al. A phase 1b single-arm trial of intratumoral oncolytic virus V937 in combination with pembrolizumab in patients with advanced melanoma: results from the CAPRA study. Cancer Immunol Immunother. 2023;72(6):1405-1415. doi:10.1007/s00262-022-03314-1
  48. Zaher A, Stephens LM, Miller AM, et al. Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy. Front Immunol. 2022;13:989000. doi:10.3389/fimmu.2022.989000
  49. Petronek MS, Allen BG, Luthe G, Stolwijk JM. Polyoxometalate nanoparticles as a potential glioblastoma therapeutic via lipid-mediated cell death. Int J Mol Sci. 2022;23(15)8263. doi:10.3390/ijms23158263
  50. Wolf DM, Yau C, Wulfkuhle J, et al. Redefining breast cancer subtypes to guide treatment prioritization and maximize response: predictive biomarkers across 10 cancer therapies. Cancer Cells. 2022;40(6):609-623.e6. doi:10.1016/j.ccell.2022.05.005
  51. Rajurkar M, Parikh AR, Solovyov A, et al. Reverse transcriptase inhibition disrupts repeat element life cycle in colorectal cancer. Cancer Discov. 2022;12(6):1462-1481. doi:10.1158/2159-8290.CD-21-1117
  52. Petronek MS, Tomanek-Chalkley AM, Monga V, et al. Detection of ferritin expression in soft tissue sarcomas with MRI: potential implications for iron metabolic therapy. Iowa Orthop J. 2022;42(1):255-262. https://pubmed.ncbi.nlm.nih.gov/35821920/
  53. Petronek MS, Spitz DR, Buettner GR, Allen Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study. J Radiat Res. 2022;63(3):378-384. doi:10.1093/jrr/rrac008
  54. Msaouel P, Goswami S, Thall PF, et al. A phase 1-2 trial of sitravatinib and nivolumab in clear cell renal cell carcinoma following progression on antiangiogenic therapy. Sci Transl Med. 2022;14(641):eabm6420. doi:10.1126/scitranslmed.abm6420
  55. Gounder MM, Rosenbaum E, Wu N, et al. A phase Ib/II randomized study of RO4929097, a gamma-secretase or notch inhibitor with or without vismodegib, a hedgehog inhibitor, in advanced sarcoma. Clin Cancer Res. 2022;28(8):1586-1594. doi:10.1158/1078-0432.CCR-21-3874
  56. Altieri DC. Wall Street doesn’t believe in this target. J Clin Oncol. 2022;40(16):1838-1840. doi:10.1200/JCO.22.0018A0
  57. Jacobson G, Fluss R, Dany-BenShushan A, et al. Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial. BMJ Open. 2022;12(3):e050169. doi:10.1136/bmjopen-2021-050169
  58. Dizman N, Meza L, Bergerot P, et al. Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial. Nat Med. 2022;28(4):704-712. doi:10.1038/s41591-022-01694-6
  59. Sung AD, Giri VK, Tang H, et al. Home-based hematopoietic cell transplantation in the United States. Transplant Cell Ther. 2022;28(4):207.e1-207.e8. doi:10.1016/j.jtct.2022.01.015
  60. Clark AS, Yau C, Wolf DM, et al. Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial. Nat Commun. 2021;12(1):6427. doi:10.1038/s41467-021-26019-y
  61. Petronek MS, St-Aubin JJ, Lee CY, et al. Quantum chemical insight into the effects of the local electron environment on T2*-based MRI. Sci Rep. 2021;11(1):20817. doi:10.1038/s41598-021-00305-7
  62. Baldelli E, Hodge KA, Bellezza G, et al. PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine. J Immunother Cancer. 2021;9(10):e002179. doi:10.1136/jitc-2020-002179
  63. Mehdi Z, Petronek MS, Stolwijk JM, et al. Utilization of pharmacological ascorbate to enhance hydrogen peroxide-mediated radiosensitivity in cancer therapy. Int J Mol Sci. 2021;22(19):10880. doi:10.3390/ijms221910880
  64. Yee D, Claudine I, Wolf DM, et al. Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer. NPJ Breast Cancer. 2021;7(1):131. doi:10.1038/s41523-021-00337-2
  65. Partridge AH, Niman SM, Ruggeri M, et al. Who are the women who enrolled in the POSITIVE trial: a global study to support young hormone receptor positive breast cancer survivors desiring pregnancy. Breast. 2021;59:327-338. doi:10.1016/j.breast.2021.07.021
  66. Gonzalez-Ericsson PI, Wulfkhule JD, Gallagher RI, et al; I-SPY2 Trial Team. Tumor-specific major histocompatibility-II expression predicts benefit to anti-PD-1/L1 therapy in patients with HER2-negative primary breast cancer. Clin Cancer Res. 2021;27(19):5299-5306. doi:10.1158/1078-0432.CCR-21-0607
  67. Petronek MS, Spitz DR, Allen BG. Iron-sulfur cluster biogenesis as a critical target in cancer. Antioxidants (Basel). 2021;10(9):1458. doi:10.3390/antiox10091458
  68. Wang VE, Blaser BW, Patel RK, et al. Inhibition of MET signaling with ficlatuzumab in combination with chemotherapy in refractory AML: clinical outcomes and high-dimensional analysis. Blood Cancer Discov. 2021;2(5):434-449. doi:10.1158/2643-3230.BCD-21-0055
  69. Weitzen R, Epstein N, Oberman B, Shevetz R, Hidvegi M, Berger R. Fermented wheat germ extract (FWGE) as a treatment additive for castration-resistant prostate cancer: a pilot clinical trial. Nutr Cancer. 2022;74(4):1338-1346. doi:10.1080/01635581.2021.1952457
  70. Rothschild SI, Zippelius A, Eboulet EI, et al; Swiss Group for Clinical Cancer Research (SAKK). SAKK 16/14: durvalumab in addition to neoadjuvant chemotherapy in patients with stage IIIA(N2) non-small-cell lung cancer-a multicenter single-arm phase II trial. J Clin Oncol. 2021;39(26):2872-2880. doi:10.1200/JCO.21.00276
  71. Campbell RA, Li J, Malone L, Levy DA. Correlative analysis of vitamin D and omega-3 fatty acid intake in men on active surveillance for prostate cancer. Urology. 2021;155:110-116. doi:10.1016/j.urology.2021.04.050
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  73. Du J, Carroll RS, Steers GJ, et al. Catalase modulates the radio-sensitization of pancreatic cancer cells by pharmacological ascorbate. Antioxidants (Basel). 2021;10(4):614. doi:10.3390/antiox10040614
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  75. Caldwell KJ, Budhraja A, Opferman JT, Pui CH, Klco JM, Rubnitz JE. Activity of venetoclax against relapsed acute undifferentiated leukemia. Cancer. 2021;127(15):2608-2611. doi:10.1002/cncr.33531
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  94. Akhavan D, Alizadeh D, Wang D, Weist MR, Shepphird JK, Brown CE. CAR T cells for brain tumors: lessons learned and road ahead. Immunol Rev. 2019;290(1):60-84. doi:10.1111/imr.12773
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